
Why choose Panorama® test?
- It uses new generation technology.
- It is the only prenatal test to distinguish between maternal and fetal DNA.
- It is the most accurate in Down syndrome screening from maternal blood.
- It screens additional important chromosomal abnormalities.
- It can be performed as early as 9 weeks into the pregnancy.
- It can be performed in case of a twin pregnancy.
- Panorama® provides the most expansive service.
- Charge-free clinical validation upon high risk result.
- Charge-free genetic counselling.
- Trusted genetic laboratory background.
Panorama® is also available for twin pregnancies from 2017 October. It is the only screening test to determine fetal fraction for both fetuses, to determine fetal gender for both fetuses, as well as to determine whether the pregnancy is mono- or dizygotic.
We provide free of charge genetic consultation pre-sampling and also after you receive your results. Where appropriate we organize the validation of high-risk results with amniocentesis within a week at a private clinic with internationally recognized specialists.
What is the Panorama® test?
Panorama® is a prenatal screening test developed by the California-based Natera laboratory, that analyses fetal DNA from maternal blood.
Panorama® determines chromosomal abnormalities that may lead to serious consequences such as Down-syndrome, Edwards-syndrome, Patau-syndrome, sex chromosome abnormalities, as well as triploidy from a single taking of maternal blood sample.
Panorama is also available for twin pregnancies from 2017 October. It is the only screening test to determine fetal fraction for both fetuses, to determine fetal gender for both fetuses, as well as to determine whether the pregnancy is mono- or dizygotic.
This test is non-invasive (does not require instrumental intervention), it gives you a reliable result, and it also accurately determines the gender of the fetus. Panorama® has a lower chance of giving a false positive result compared to other prenatal screening tests. Another advantage of the test is that it can be performed from the 9. week of pregnancy.

What does Panorama® screen for?
The Panorama® test screens for 13 different serious chromosomal abnormalities that may affect the fetus.
Chromosome number aberrations
- Down Syndrome (trisomy 21)
- Edwards Syndrome (trisomy 18)
- Patau Syndrome (trisomy 13)
- Triplody
Sex chromosome abnormalites
- Klinefelter syndrome
- Triple X syndrome
- Turner syndrome
- Jacob syndrome
Microdeletions
- 22q11.2 deletion / DiGeorge syndrome
- 1p36 deletion syndrome
- Angelman syndrome
- Cri-du-chat syndrome
- Prader-Willi syndrome
+ fetal gender determination (upon request from completed 12. week)

Chromosome abnormalites
- Trisomy 21 (Down syndrome)
- Trisomy 18 (Edwards syndrome)
- Trisomy 13 (Patau syndrome)
- Triploidy
Sex chromosome abnormalities
- Jacob syndrome (XYY)
- X-monosomy (Turner syndrome)
- Triple X syndrome (XXX)
- Klinefelter syndrome (XXY)
Microdeletions
- Prader-Willi syndrome
- 22q11.2 deletion
- Angelman syndrome
- Cri-du-chat syndrome
- 1p36 deletion syndrome
Fetal screening and testing options
Expecting parents have numerous opportunities to use different diagnostic tests to exclude chromosomal abnormalities of the fetus during pregnancy. Ask your specialist for the best prenatal test for you. The advantage of non-invasive screening (ultrasound and maternal blood-based tests) is the fact they do not cause miscarriage.

Panorama® test
Panorama® test is a new type of non-invasive prenatal screening test. Panorama® screens fetal DNA circling in maternal blood with a single taking of blood from the mother. This test detects common chromosome abnormalities with an incomparably large accuracy compared to conventional combined tests.

Conventional combined tests
The traditional screening tests in the first trimester analyse hormones and other biochemical markers from maternal blood and are also complemented with ultrasound screening. Based on these results it is possible to determine a probability of a certain chromosome abnormality (primarily trisomy 21, Down syndrome).

Ultrasound screening
Both first and second-trimester ultrasound screening gives detailed information about fetal size, hence defects due to chromosome aberrations can be detected. Any type of size anomaly of the fetus may refer to abnormality due to chromosome aberrations, on the other hand, normal fetal size decreases the chance of such defects.
The so-called invasive procedures, such as chorion biopsy or amniocentesis, are used to directly detect chromosome abnormalities, and on average have a 0,5% risk of miscarriage. This means that 1 in 200 procedures ends in an abortion of the fetus.
Invasive diagnostic procedures
- Chorionic villus sampling
- Amniocentesis
Advantages of the Panorama® test
The Panorama® test is recommended for any expecting woman of any age who would like to know more about the health of their fetuses. It is a known fact, that expecting women over 35-years-of-age have a larger risk of a chromosome abnormality, eg. Down syndrome. Moreover, Panorama test optionally also screens for microdeletions, which are quite common chromosome defects, but their risk does not depend on maternal age.
To date, Panorama® test is not available in the following cases:
-Pregnancies where the mother have had bone marrow transplantation
-Twin pregnancies, where donor eggs have been used

Twin pregnancies
Panorama® test is now available in twin pregnancies and in case of egg donations.
Panorama® offers expansive screening options in twin pregnancies.
Only Panorama® can detect:
- whether the twin pregnancy is mono or dizygotic
- the unique fetal fractions for both fetuses, which is necessary for an accurate result
- fetal gender for both fetuses
- sex chromosome abnormalities in monozygotic twin pregnancies
What information do the test results give you?
Panorama® has an extremely high accuracy, above 99.4%, which aids the detection of fetal chromosome abnormalities.
- Low risk
- High risk
- No results
Panorama® test less often, compared to other screening methods, may show a high-risk result for a healthy fetus (false positive result) or may show a low-risk result for chromosomal aberrations (false negative), therefore it is necessary to consult with a specialist after receiving the results.
